Genetic Variations in Magnesium-Related Ion Channels May Affect Diabetes Risk

Interactions of diet, genetics, and ethnicity may affect magnesium-mediated diabetes risk, according to a new study. After identifying 17 magnesium-related ion channel genes, investigators examined whether variations in the genes were associated with type 2 diabetes risk in 7287 African-American and 3285 Hispanic-American postmenopausal women. Several variants stood out in the Journal of Nutrition study. Among Hispanic American women with high magnesium intake, those with the rs8028189 variant on the NIPA2 gene had a 35% lower diabetes risk than women overall. Black women showed a 16% lower risk for each copy of the CNNM1 gene with the rs6584273 variant. 

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Interactions of diet, genetics, and ethnicity may affect magnesium-mediated diabetes risk, according to a new study. After identifying 17 magnesium-related ion channel genes, investigators examined whether variations in the genes were associated with type 2 diabetes risk in 7287 African-American and 3285 Hispanic-American postmenopausal women. Several variants stood out in the Journal of Nutrition study. Among Hispanic American women with high magnesium intake, those with the rs8028189 variant on the NIPA2 gene had a 35% lower diabetes risk than women overall. Black women showed a 16% lower risk for each copy of the CNNM1 gene with the rs6584273 variant. 

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