Drug May Have Benefits for Sympathetic Nerve Activity, Arterial Stiffness in CKD

People with CKD often have an overactivation of the sympathetic nervous system, which contributes to increased risks for cardiovascular events. However, tetrahydrobiopterin may be able to dial back this process. In a randomized study of 36 patients with CKD, the drug had positive effects on the sympathetic nervous system and some measures of arterial stiffness. The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology findings noted reduced neuronal nitric oxide (NO) leads to increased central sympathetic nervous system activity, and tetrahydrobiopterin is an essential cofactor for NO synthase that increases NO bioavailability.

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People with CKD often have an overactivation of the sympathetic nervous system, which contributes to increased risks for cardiovascular events. However, tetrahydrobiopterin may be able to dial back this process. In a randomized study of 36 patients with CKD, the drug had positive effects on the sympathetic nervous system and some measures of arterial stiffness. The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology findings noted reduced neuronal nitric oxide (NO) leads to increased central sympathetic nervous system activity, and tetrahydrobiopterin is an essential cofactor for NO synthase that increases NO bioavailability.

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