Anti-Inflammatory Drug’s Effects Point to New Diabetes Treatment Strategy

New research reveals how amlexanox, an anti-inflammatory drug, reverses obesity, diabetes, and fatty liver disease. Investigators found that amlexanox exerts its effects through subcutaneous fat cells by increasing the level of a second messenger molecule called cAMP. In turn, cAMP increases the rate by which cells metabolize fat so that the animal loses weight. Amlexanox also coaxes fat cells to release the hormone interleukin-6, which then travels in the circulation to the liver, where it reduces glucose production and thereby lowers overall blood sugar levels. The Nature Communications findings may lead to new treatments against type 2 diabetes.

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New research reveals how amlexanox, an anti-inflammatory drug, reverses obesity, diabetes, and fatty liver disease. Investigators found that amlexanox exerts its effects through subcutaneous fat cells by increasing the level of a second messenger molecule called cAMP. In turn, cAMP increases the rate by which cells metabolize fat so that the animal loses weight. Amlexanox also coaxes fat cells to release the hormone interleukin-6, which then travels in the circulation to the liver, where it reduces glucose production and thereby lowers overall blood sugar levels. The Nature Communications findings may lead to new treatments against type 2 diabetes.

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