Gene Editing Technology

Listed below are some resources on gene editing technology - background, pros and cons, and potential applications to practice. We encourage you to use the TalkBack button or write info@kidneynews.org to suggest other resources that may be helpful to your colleagues.

Background: 

The CRISPR growth spurt: From bench to clinic http://www.jmb.or.kr/journal/viewJournal.html?doi=10.4014/jmb.1607.07005

Genome Editing: CRISPR/Cas9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099421/

Gene Editing Approaches in Human Induced Pluripotent Stem Cells http://www.mdpi.com/2073-4409/6/1/5

CRISPR: A game-changing genetic engineering technique http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/

 The CRISPR Revolution http://www.sciencemag.org/topic/crispr

​ Questions and Answers about CRISPR https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr

Pros and Cons:

 First results of CRISPR gene editing on normal embryos https://www.newscientist.com/article/2123973-first-results-of-crispr-gene-editing-of-normal-embryos-released/

 Genome Edting for Inborn Errors of Metabolism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327528/ 

 CRISPR the Disruptor http://www.nature.com/news/crispr-the-disruptor-1.17673

 CRISPR Won't Fully Fix Sick People Anytime Soon http://www.sciencemag.org/news/2016/05/gene-editor-crispr-won-t-fully-fix-sick-people-anytime-soon-here-s-why

 Gene Editing: Scientists Urge Caution http://news.berkeley.edu/2015/03/19/scientists-urge-caution-in-using-new-crispr-technology-to-treat-human-genetic-disease/

 NIH Statement Re Funding of Research Using Gene Editing on Human Embryos https://www.nih.gov/about-nih/who-we-are/nih-director/statements/statement-nih-funding-research-using-gene-editing-technologies-human-embryos

 Embryo Editing Sparks Epic Debate http://www.nature.com/news/embryo-editing-sparks-epic-debate-1.17421

Potential Clinical Applications:

CRISPR may speed pig-to-human transplants https://www.technologyreview.com/s/603857/crispr-may-speed-pig-to-human-transplants/

 First CRISPR Clinical Trial Gets Green Light from Panel http://www.nature.com/news/first-crispr-clinical-trial-gets-green-light-from-us-panel-1.20137

 Therapeutic Genome Editing: Prospects and Challenges http://zlab.mit.edu/assets/reprints/Cox_D_Nat_Med_2015.pdf

 CRISPR Reduces Disease Symptoms in Living Animals http://www.genengnews.com/gen-news-highlights/crispr-reverses-disease-symptoms-in-living-animals-for-first-time/81249682/

 Gene Editing and HIV Resistance http://sitn.hms.harvard.edu/flash/2014/gene-editing-technique-allows-for-hiv-resistance/

 Gene Editing Unleashed on RNA http://www.nature.com/news/crispr-gene-editing-system-unleashed-on-rna-1.20030

 

All Kidney News Online resource lists are available here.

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Listed below are some resources on gene editing technology - background, pros and cons, and potential applications to practice. We encourage you to use the TalkBack button or write info@kidneynews.org to suggest other resources that may be helpful to your colleagues.

Background: 

The CRISPR growth spurt: From bench to clinic http://www.jmb.or.kr/journal/viewJournal.html?doi=10.4014/jmb.1607.07005

Genome Editing: CRISPR/Cas9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099421/

Gene Editing Approaches in Human Induced Pluripotent Stem Cells http://www.mdpi.com/2073-4409/6/1/5

CRISPR: A game-changing genetic engineering technique http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/

 The CRISPR Revolution http://www.sciencemag.org/topic/crispr

​ Questions and Answers about CRISPR https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr

Pros and Cons:

 First results of CRISPR gene editing on normal embryos https://www.newscientist.com/article/2123973-first-results-of-crispr-gene-editing-of-normal-embryos-released/

 Genome Edting for Inborn Errors of Metabolism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327528/ 

 CRISPR the Disruptor http://www.nature.com/news/crispr-the-disruptor-1.17673

 CRISPR Won't Fully Fix Sick People Anytime Soon http://www.sciencemag.org/news/2016/05/gene-editor-crispr-won-t-fully-fix-sick-people-anytime-soon-here-s-why

 Gene Editing: Scientists Urge Caution http://news.berkeley.edu/2015/03/19/scientists-urge-caution-in-using-new-crispr-technology-to-treat-human-genetic-disease/

 NIH Statement Re Funding of Research Using Gene Editing on Human Embryos https://www.nih.gov/about-nih/who-we-are/nih-director/statements/statement-nih-funding-research-using-gene-editing-technologies-human-embryos

 Embryo Editing Sparks Epic Debate http://www.nature.com/news/embryo-editing-sparks-epic-debate-1.17421

Potential Clinical Applications:

CRISPR may speed pig-to-human transplants https://www.technologyreview.com/s/603857/crispr-may-speed-pig-to-human-transplants/

 First CRISPR Clinical Trial Gets Green Light from Panel http://www.nature.com/news/first-crispr-clinical-trial-gets-green-light-from-us-panel-1.20137

 Therapeutic Genome Editing: Prospects and Challenges http://zlab.mit.edu/assets/reprints/Cox_D_Nat_Med_2015.pdf

 CRISPR Reduces Disease Symptoms in Living Animals http://www.genengnews.com/gen-news-highlights/crispr-reverses-disease-symptoms-in-living-animals-for-first-time/81249682/

 Gene Editing and HIV Resistance http://sitn.hms.harvard.edu/flash/2014/gene-editing-technique-allows-for-hiv-resistance/

 Gene Editing Unleashed on RNA http://www.nature.com/news/crispr-gene-editing-system-unleashed-on-rna-1.20030

 

All Kidney News Online resource lists are available here.